917P Head and neck cancer patients under (chemo-)radiotherapy undergoing nutritional intervention: Results from the prospective randomized HEADNUT-trial

Patients with head and neck squamous cell carcinoma (HNSCC) are often malnourished before starting the primary or adjuvant radiotherapy (RT) chemoradiotherapy (CRT). Due to therapy related adversary effects of RT CRT number patients rises 88% during ongoing therapy. Malnutrition can have a negative influence on therapycourse clinical outcome. There still not enough prospective, randomized studies nutritional status (C-)RT From October 2018 2020, 61 HSNCC, into control intervention group (IG), was measured at beginning, every 2 weeks end The risk malnutrition evaluated established screening tools (NRS-2002, MUST, Nutriscore) 3-day diet diaries, underwent examinations, laboratory analyses bioelectrical impedance analyses. In addition, IG had individualized counseling weeks. Before therapy, median BMI all 23.8 (14.5-37.2) kg/m2 after fell 22.9 (16.8-33) (p<0.001). baseline fat-free mass index (FFMI) for 18.1 (14-24.7) kg/m2, which dropped 17.8 (13.4-21.6) ending Control lost more weight compared compliant participants <22 kg/m2(p=0.0015, CI: 0.33-2.95). MUST only questionnaire, showed high sensitivity (86%) specificity (88%) in predicting malnutrition. 2-year overall survival rate 70% 79% (log-rank p=0.79). A clear impact observed pretherapeutic phase angle, posttherapeutic FFMI albumin level blood as indicators p=0.002, p=0.008, p=0.016). has an adverse patients’ outcome undergoing (chemo-) radiotherapy. Pretherapeutic be considered survival.